UPRADONE is an anti-ulcer antiemetic which contains two active substances, pantoprazole and domperidone. Pantoprazole is a selective proton pump inhibitor, which reduces acid production in the stomach. Domperidone is a gastric motility modifier that allows food to pass through the oesophagus, stomach and intestine more quickly. The food bolus remains in these organs for a short period of time, thus preventing reflux.
UPRADONE is indicated in the following cases:

Reflux of oesophagitis (inflammation of the oesophagus accompanied by acid regurgitation from the stomach);
Helicobacter pylori infection in patients with gastric and duodenal ulcers, in combination with two antibiotics;
Active gastric and duodenal ulcers;
Zollinger-Ellison syndrome.

Take this medicine exactly as prescribed by your doctor. Ask your doctor or pharmacist if you have any doubts.

Dosage and administration
Capsules should be swallowed whole with water, preferably before meals. Do not open, break, chew or crush the capsules.
To treat reflux esophagitis: The usual dose is 1 capsule daily for 4 to 8 weeks. Your doctor may repeat the treatment with the same dose if necessary.
In the treatment of Helicobacter pylori infection in combination with two antibiotics (eradication therapy), the usual dose of UPRADONE is 1 capsule twice daily before meals/breakfast with 500 mg clarithromycin morning and evening and 1 g amoxicillin morning and evening, for 7 to 14 days. Your doctor may prescribe other antibiotic combinations with UPRADONE.
Treatment of gastric and duodenal ulcers: The usual dose is 1 capsule per day. Your doctor will advise you on the duration of treatment. The treatment period for duodenal ulcers is 2 to 4 weeks and treatment of gastric ulcers usually lasts 4 to 8 weeks.
Treatment of Zolliger-Ellison syndrome: The recommended initial dose is 2 capsules. The dosage may be adjusted depending on the severity. When your doctor increases the dose, it is recommended that the dose be divided into 2 doses.

Prescription medicine. Ask your doctor for advice.