> THERAPEUTIC INDICATION

Flucloxacillin is an antibiotic of the beta-lactam family of semi-synthetic isoxazole penicillins. It is a bactericidal antibiotic that is resistant to staphylococcal penicillinase and gastric acidity and acts against gram-positive bacteria.

FUCLO® is indicated for the treatment of:
Skin and soft tissue infections:
Boils, cellulitis, infected burns, abscesses, skin infections, ulcers, eczema, acne, impetigo, furunculosis and infected wounds.
Lower respiratory tract infections:
Pneumonia, lung abscess, emphysema, sinusitis, pharyngitis, otitis media and otitis externa, tonsillitis and peritonsillar abscess.
Other infections:
Osteomyelitis, urinary tract infections, enteritis, meningitis, endocarditis and septicaemia.
Flucloxacillin may also be indicated as a prophylactic agent during major surgical procedures such as cardiothoracic or orthopaedic surgery.

Parenteral therapy may be indicated if the oral route is inappropriate.

> DOSAGE AND ADMINISTRATION

FUCLO® should only be taken on medical advice. If you have any questions, talk to your doctor or pharmacist.

Dosage and method of administration
The dosage depends on the age, weight and renal function of the patient and the severity of the infection.

Adults and children over 14 years:
Intramuscular or intravenous :
1 to 3 g/day divided into 4 IM or IV administrations.

In case of severe infections (osteomyelitis, endocarditis): up to 8 g/day in 4 rapid infusions (20-30 min). No infusion should exceed 2 g.
Haemolytic streptococcal A, B infections require a minimum of 10 days of treatment.

For surgical prophylaxis: 2 g IV (bolus or infusion) at induction of anaesthesia. Repeat every 6 hours for 24 hours in orthopaedic or vascular surgery and for 48 hours in coronary or cardiac surgery.

Children under 14 years:
25-50mg/kg/day to be administered IM or IV and divided into 3 or 4 administrations.

If necessary, the dosage may be increased to 100 mg/kg/day by parenteral administration divided into three or four administrations, but no injection may exceed 33 mg/kg at a time.

Children 10 to 14 years of age usually receive a daily dose of 1.5 g to 2 g in 3 or 4 divided doses.
Children aged 6 to 10 years usually receive a daily dose of 0.7g to 1.5g in 3 or 4 divided doses.
Dose adjustment may be necessary in premature, newborn and breast-fed babies.

In renal failure:
If creatinine clearance falls below 10 ml/min, the recommended dosage is 1 g every 8 to 12 hours (in the anuric patient, the dosage is 1 g every 12 hours).
Dialysis should not be accompanied by an additional dose.