> DOSAGE AND ADMINISTRATION
Dosage
The total dose should be given in 6 doses of 1 tablet, spread over a total of 60 hours, according to the following schedule
First dose at the time of diagnosis: 1 tablet.
Then 5 doses of 1 tablet at 8, 24, 36, 48 and 60 hours after the first dose.

Method of administration
Tablets for oral administration.
In order to improve the absorption of the active ingredients, Cofantrine should be taken with a meal or with a milk drink. Cofantrine may be used with water in case of food intolerance, but systemic exposure may be reduced. If vomiting occurs within one hour, a full dose should be re-administered.

This medicine is subject to medical prescription, ask your doctor or pharmacist for advice.

> DOSAGE AND ADMINISTRATION
Dosage
Adults and children weighing more than 35 kg:
The total dose should be given in 6 doses of 4 tablets (i.e. 24 tablets) spread over a total of 60 hours according to the following schedule:
First dose at the time of diagnosis: 4 tablets.
Then 5 doses of 4 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Body weight from 25 kg to less than 35 kg:
First dose at diagnosis: 3 tablets
Then 5 doses of 3 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Body weight 15 kg to less than 25 kg:
First dose at diagnosis: 2 tablets
Then 5 doses of 2 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Mode of administration
Tablets for oral administration.
In order to improve the absorption of the active ingredients, Cofantrine should be taken with a meal or with a milk drink. Cofantrine may be used with water in case of food intolerance, but systemic exposure may be reduced. If vomiting occurs within one hour of dosing, a full dose should be re-administered.
For administration to young children and infants, the tablet(s) may be crushed.

This medicine is subject to medical prescription, ask your doctor or pharmacist for advice.

> DOSAGE AND ADMINISTRATION
Dosage
Adults and children 12 years of age or older and weighing 35 kg or more:
The total dose should be given in 6 doses of 4 tablets (i.e. 24 tablets) spread over a total of 60 hours according to the following schedule:
First dose at the time of diagnosis: 4 tablets.
Then 5 doses of 4 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Body weight from 25 kg to less than 35 kg:
First dose at diagnosis: 3 tablets
Then 5 doses of 3 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Body weight 15 kg to less than 25 kg:
First dose at diagnosis: 2 tablets
Then 5 doses of 2 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Body weight 5 kg to less than 15 kg:
First dose at time of diagnosis: 1 tablet.
Then 5 doses of 1 tablet 8, 24, 36, 48 and 60 hours after the first dose.

Method of administration
Tablets for oral administration.
Dissolve the tablet in a milk drink or water, shake the contents and drink.
In order to improve the absorption of the active ingredients, Cofantrine should be taken with a meal or with a milk drink. In case of vomiting within one hour of taking, a full dose should be re-administered.

This medicine is subject to medical prescription, ask your doctor or pharmacist for advice.

> DOSAGE AND METHOD OF ADMINISTRATION
Do not take COFANTRINE without medical advice. If you have any questions ask your doctor or pharmacist.
Preparation of COFANTRINE suspension
To prepare 60 ml of the suspension, add water and shake the bottle until all the powder is dispersed. Then slowly add more water to the mark on the bottle. Use only boiled and cooled water.
Shake well before each use.
After reconstitution, the suspension is stable for at least 7 days. Store the reconstituted suspension in a refrigerator (between 2°C and 8°C).

Dosage and administration
After each dose, give your child a high-fat meal or a high-fat drink such as milk.
Your doctor will tell you exactly how much COFANTRINE to give your child. If you are not sure about the dose of COFANTRINE or when to take it, ask your doctor or pharmacist.

If your child vomits within an hour of taking the medicine, give him/her another dose and inform your doctor or pharmacist.

As this medicine is subject to medical prescription, ask your doctor or pharmacist for advice.

> DOSAGE AND METHOD OF ADMINISTRATION
Dosage
Adults and children 12 years of age or older and weighing 35 kg or more:
The total dose should be given in 6 doses of 4 tablets (i.e. 24 tablets) spread over a total of 60 hours according to the following schedule:
First dose at the time of diagnosis: 4 tablets.
Then 5 doses of 4 tablets at 8, 24, 36, 48 and 60 hours after the first dose.

Children and infants weighing from 5 kg to less than 35 kg:
Body weight from 25 kg to less than 35 kg:
First dose at time of diagnosis: 3 tablets
Then 5 doses of 3 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Body weight 15 kg to less than 25 kg:
First dose at diagnosis: 2 tablets
Then 5 doses of 2 tablets 8, 24, 36, 48 and 60 hours after the first dose.

Body weight 5 kg to less than 15 kg:
First dose at time of diagnosis: 1 tablet.
Then 5 doses of 1 tablet 8, 24, 36, 48 and 60 hours after the first dose.

Method of administration
Tablets for oral administration.
Dissolve the tablet in a milk drink or water, shake the contents and drink.
In order to improve the absorption of the active ingredients, LUFANTER should be taken with a meal or with a milk drink. LUFANTER may be used with water in cases of food intolerance, but systemic exposure may be reduced. If vomiting occurs within one hour, a full dose should be re-administered.

This medicine is subject to medical prescription, ask your doctor or pharmacist for advice.

> POSOLOGIE ET MODE D’ADMINISTRATION
Posologie
La dose totale sera administrée en 6 prises de 2 comprimés (soit 12 comprimés) réparties sur une durée totale de 60 heures selon le schéma suivant :
Première prise au moment du diagnostic : 2 comprimés.
Puis 5 prises de 2 comprimés 8, 24, 36, 48 et 60 heures après la première prise.

Mode d’administration
Comprimés pour une administration par voie orale.
Afin d’améliorer l’absorption des principes actifs, LUFANTER doit être pris au cours d’un repas ou avec une boisson lactée. LUFANTER pourra être utilisé avec de l’eau en cas d’intolérance alimentaire, mais l’exposition systémique risque alors d’être diminuée. En cas de vomissements dans l’heure qui suit la prise, une dose complète sera réadministrée.

Médicament sur prescription médicale, demandez l’avis de votre médecin ou pharmacien.

> DOSAGE AND METHOD OF ADMINISTRATION
Dosage
The total dose should be administered in 6 doses of 1 sachet over a total of 60 hours according to the following schedule:
First dose at the time of diagnosis: 1 sachet
Then 5 doses of 1 sachet at 8, 24, 36, 48 and 60 hours after the first dose.
Method of administration
Reconstitution: Dissolve the contents of the sachet in a glass of lukewarm water. Mix thoroughly. Consume the entire contents of the glass immediately. After a dose, take food or drinks rich in fat such as milk.

If vomiting occurs within 1 hour of taking LUFANTER® sachet, the dose should be taken again

> DOSAGE AND ADMINISTRATION
Adults and children over 20 kg: 2.4 mg artesunate per kg, to be administered by intravenous (IV) or intramuscular (IM) injection; at intervals of 0, 12, and 24 hours, and then once daily until oral treatment can be given as a relay.
Adults and children under 20 kg: 3 mg artesunate per kg, administered by intravenous (IV) or intramuscular (IM) injection; at intervals of 0, 12, and 24 hours, then once daily until oral therapy can be initiated.
MALAVAN should be administered for a minimum of 24 hours (in 3 doses), regardless of the patient’s ability to tolerate earlier oral therapy.
Treatment may be extended for up to 7 days in total.

Reconstitution of MALAVAN :

• Add the 2 ml ampoule of sodium bicarbonate to the vial containing the artesunate powder.
• Shake the bottle for a few minutes to mix well, until the powder is completely dissolved and the solution is clear.
• Remove excess air with the syringe.
• Dilute the solution according to the type of injection chosen, as described below (then inject immediately, the reconstituted solution must be discarded if not used within one hour):

Intravenous (IV) injection

Add the 10 ml ampoule of sodium chloride injection to the vial containing the reconstituted artesunate solution. This will create a 12 ml solution, containing artesunate 10mg/ml. Shake to mix well, the resulting solution should remain clear.

The volume required is equal to :

For people under 20 kg: V = 3.0 mg x body weight (kg)/10

For people over 20 kg: V = 2.4 mg x body weight (kg)/10

Withdraw the required volume of artesunate solution from the vial with a syringe and inject slowly by intravenous route (3 or 4 ml per minute).
Not to be given as an IV infusion.

Intramuscular (IM) injection:

Add 4 ml of 0.9% Sodium Chloride Injection to the vial containing the reconstituted artesunate solution. This will give a 6 ml solution, containing 20 mg/ml artesunate. Shake to mix well, the solution obtained must remain clear.

The necessary volume is equal to :

For people under 20 kg: V = 3.0 mg x body weight (kg)/20

For people over 20 kg: V = 2.4 mg x body weight (kg)/20

Take the necessary volume of artesunate solution from the vial with a syringe and inject slowly by intramuscular route.

Prescription medicine. Ask your doctor for advice.

> DOSAGE AND METHOD OF ADMINISTRATION
Dosage :
Adults and children over 20 kg: 2.4 mg artesunate per kg, to be administered by intravenous (IV) or intramuscular (IM) injection; at intervals of 0, 12, and 24 hours, and then once daily until oral treatment can be given in relay.
Adults and children under 20 kg: 3 mg artesunate per kg, administered by intravenous (IV) or intramuscular (IM) injection; at intervals of 0, 12, and 24 hours, then once daily until oral therapy can be initiated.
MALAVAN should be administered for a minimum of 24 hours (in 3 doses), regardless of the patient’s ability to tolerate earlier oral therapy.
Treatment may be extended for a total of up to 7 days.

Reconstitution of MALAVAN :

• Add the 1 ml ampoule of sodium bicarbonate to the vial containing the artesunate powder.
• Shake the bottle for a few minutes to mix well, until the powder is completely dissolved and the solution is clear.
• Remove excess air with the syringe.
• Dilute the solution according to the type of injection chosen, as described below (then inject immediately, the reconstituted solution must be discarded if not used within one hour):

Intravenous (IV) injection

Add the 5 ml ampoule of sodium chloride injection to the vial containing the reconstituted artesunate solution. This will create a 6 ml solution, containing artesunate 10mg/ml. Shake to mix well, the resulting solution should remain clear.

The volume required is equal to :

For people under 20 kg: V = 3.0 mg x body weight (kg)/10

For people over 20 kg: V = 2.4 mg x body weight (kg)/10

Withdraw the required volume of artesunate solution from the vial with a syringe and inject slowly by intravenous route (3 or 4 ml per minute).
Not to be given as an IV infusion.

Intramuscular (IM) injection:

Add 2 ml of 0.9% Sodium Chloride Injection to the vial containing the reconstituted artesunate solution. This will give a 3 ml solution, containing 20 mg/ml artesunate. Shake to mix well, the solution obtained must remain clear.

The necessary volume is equal to :

For people under 20 kg: V = 3.0 mg x body weight (kg)/20

For people over 20 kg: V = 2.4 mg x body weight (kg)/20

Take the necessary volume of artesunate solution from the vial with a syringe and inject slowly by intramuscular route.

Prescription medicine. Ask your doctor for advice.

> DOSAGE AND ADMINISTRATION
Adults and children over 20 kg: 2.4 mg artesunate per kg, to be administered by intravenous (IV) or intramuscular (IM) injection; at intervals of 0, 12, and 24 hours, and then once daily until oral treatment can be given as a relay.
Adults and children under 20 kg: 3 mg artesunate per kg, administered by intravenous (IV) or intramuscular (IM) injection; at intervals of 0, 12, and 24 hours, then once daily until oral therapy can be initiated.

MALAVAN should be given for a minimum of 24 hours (in 3 doses), regardless of the patient’s ability to tolerate earlier oral treatment.
The doctor may decide to extend your treatment to a total of up to 7 days if he/she considers it necessary.

Reconstitution of MALAVAN Injection:

Add the 0.5 ml ampoule of sodium bicarbonate to the vial containing the artesunate powder.
Shake the vial for a few minutes to mix thoroughly until the powder is completely dissolved and the solution is clear.
After reconstitution, the solution must be diluted according to the type of injection chosen, as described below:

Intravenous (IV) injection

Add the 2.5 ml ampoule of 0.9% sodium chloride injection to the vial containing the reconstituted artesunate solution. This will create a 3 ml solution, containing artesunate 10mg/ml. Shake to mix well, the resulting solution should remain clear.

The volume required is equal to :

For people under 20 kg: V = 3.0 mg x body weight (kg)/10

For people over 20 kg: V = 2.4 mg x body weight (kg)/10

Intramuscular (IM) injection
Add 1 ml of 0.9% Sodium Chloride Injection to the vial containing the reconstituted artesunate solution. This will create a 1.5 ml solution, containing artesunate 20mg/ml. Shake to mix well, the resulting solution should remain clear.

The volume required is equal to :

For people under 20 kg: V = 3.0 mg x body weight (kg)/20

For people over 20 kg: V = 2.4 mg x body weight (kg)/20

The reconstituted artesunate solution should always be used immediately, once it is clear.
The reconstituted solution must be discarded if not used within one hour.

Prescription medicine. Ask your doctor for advice.