> INDICATION THERAPEUTIQUE

UPRACID contains the active substance pantoprazole. UPRACID is a "selective proton pump inhibitor", a medicine that reduces the amount of acid your stomach produces. It is intended to treat acid-related stomach and intestinal conditions.
UPRACID is used in adults and adolescents aged 12 years and over in :

• the symptoms (e.g. heartburn, acid regurgitation, pain on swallowing) associated with gastroesophageal reflux disease caused by acid reflux from the stomach.
• long-term management of reflux oesophagitis (inflammation of the oesophagus associated with gastric acid regurgitation) and prevention of its recurrence.

UPRACID is used in adults in :

• Prevention of non-steroidal anti-inflammatory drug (NSAID)-induced gastric and duodenal ulcers (e.g. ibuprofen) in at-risk patients requiring continuous NSAID use.
• Infection with a bacterium called Helicobacter pylori in patients with duodenal and gastric ulcers, in combination with two antibiotics (eradication therapy). The aim is to eliminate the bacteria and thus reduce the likelihood of recurrence of these ulcers;
• Zollinger-Ellison syndrome and other conditions that cause excess stomach acid.

> DOSAGE AND ADMINISTRATION

Always take this medicine exactly as directed by your doctor or pharmacist. Check with your doctor or pharmacist if you are not sure. Mode d’administration
Take the tablets one hour before a meal without chewing or crushing them. Swallow them whole with a little water.

The recommended dose is :

 Adults and adolescents aged 12 years and over

- For the treatment of symptoms (e.g. heartburn, acid regurgitation, pain on swallowing) associated with gastroesophageal reflux disease.

The usual dose is one tablet of UPRACID 20 per day. This dose usually brings relief within 2 to 4 weeks - at the latest after another 4 weeks. Your doctor will tell you how long you should continue to take this medicine. Afterwards, a possible recurrence of symptoms can be prevented by taking one tablet a day, if necessary.

-For long-term management and prevention of recurrence of reflux esophagitis
The usual dose is one UPRADIC 20 tablet per day. In case of relapse, the dose can be doubled. In this case you can use UPRACID 40 mg tablet, one tablet per day. After recovery, you can reduce the dose to one UPRACID 20 mg tablet per day.

-In the treatment of reflux esophagitis
The usual dose is one UPRACID 40 tablet per day. Your doctor may tell you to increase the dose to 2 tablets of UPRACID 40 per day. The usual duration of treatment for reflux esophagitis is 4 to 8 weeks. Your doctor will tell you how long you should continue to take the medicine.

Adults
-For the prevention of duodenal and gastric ulcers in patients who require continuous NSAID therapy
The usual dose is one tablet of UPRACID 20 per day.

- For the treatment of infection caused by a bacterium called Helicobacter pylori in patients with duodenal and gastric ulcers, in combination with two antibiotics (eradication therapy)

One UPRACID 40 tablet twice a day plus two antibiotic tablets, either amoxicillin or clarithromycin and metronidazole (or tinidazole) each taken twice a day with your pantoprazole tablet. Take the first pantoprazole tablet 1 hour before breakfast and the second pantoprazole tablet 1 hour before dinner. Follow your doctor's instructions and make sure you read the instructions for these antibiotics. The usual duration of treatment is one to two weeks.

- In the treatment of gastric and duodenal ulcers

The usual dose is one URPACID 40 tablet per day. After consulting your doctor, the dose may be doubled.
Your doctor will tell you how long you should continue to take the medicine. The usual duration of treatment for gastric ulcers is 4 to 8 weeks. The usual duration of treatment for duodenal ulcers is 2 to 4 weeks.

-  In the long-term treatment of Zollinger-Ellison syndrome and other conditions characterised by excessive gastric acid production.

The recommended starting dose is usually two tablets of UPRACID 40 per day.
Take both tablets 1 hour before a meal. Your doctor may adjust the dosage later depending on how much stomach acid you produce. If your doctor has prescribed more than two tablets a day, divide them into two doses.

 Patients with kidney problems

If you have kidney problems, you should not take UPRACID to eradicate Helicobacter pylori.If you have kidney problems, you should not take UPRACID to eradicate Helicobacter pylori. If you have kidney problems, you should not take UPRACID to eradicate Helicobacter pylori.

Patients with liver problems.

If you have severe liver problems, you should not take more than one 20 mg tablet a day.

Use in children and adolescents
These tablets should not be used in children under 12 years of age.

Prescription medicine. Ask your doctor for advice.